Exit the M74 at junction 21, signposted for Kirkpatrick Fleming. Take care at the north bound exit. The slip road brings you straight onto the B7076, the road between Kirkpatrick and Gretna.
There are direct bus connections with Annan, Gretna and Lockerbie. Bus times can be found on bustimes.org.uk or on travelinescotland.com.
Kirkpatrick Fleming is on National Cycle Route 74 from Carlisle to South Lanarkshire and on stage 28 of the Mapmyride LEJOG trip, Carlisle to Lockerbie.